Administration of Cordarone in divided doses with meals is suggested for total daily doses of 1,000 mg or higher, or when gastrointestinal intolerance occurs. Tell your doctor immediately if you experience any of these serious side effects: cough, fever, cordarone kopen zonder recept chills, chest pain, difficult or painful breathing, coughing up blood, severe stomach pain, fatigue, yellowing eyes or skin, or dark urine. In addition to the interactions noted above, chronic weeks oral Cordarone administration impairs metabolism of phenytoin, dextromethorphan, and methotrexate. In order to insure that an antiarrhythmic effect will be observed without waiting several months, loading doses are required. There have been case reports of increased steady-state levels of quinidine, procainamide, and phenytoin during concomitant therapy with amiodarone.